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FIGURE 1 Since the diet is an essential environmental factor impacting intestinal microbiota composition, increasing attention has been given to its role in the pathogenesis, progression, and activity of rheumatic diseases ( Mechanisms Underlying Probiotics Effects on Gut Microbiota, Immune System and Rheumatoid Arthritis A link between the composition and activity of GM and human health and disease has been previously described ( Probiotic’s Direct Mechanisms of Immune System Modulation Specific probiotic bacteria modulate the immune response by affecting different cells involved in innate and acquired immunity, such as epithelial cells and dendritic cells (DCs), natural killer cells (NK), macrophages, and lymphocytes ( The innate immune system develops the primary response to pathogens after activation of the pattern recognition receptors (PRRs), which are expressed on immune and non-immune cells, such as NK cells, DCs, macrophages, fibroblasts, and epithelial cells ( Concerning the adaptive immune response, T cells are central to immune balance ( Probiotic’s Indirect Mechanisms of Immune System Modulation Probiotics can also interact with the host immune system through indirect mechanisms, which involve the modulation of GM
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At 6 hpi, mice received either 100 mg kg −1 KL1 or the vehicle (7% DMSO, 40% PEG300 and 53% sterile H 2 O)
